Open tibial fractures grade IIIC treated successfully with external fixation, negative-pressure wound therapy and recombinant human bone morphogenetic protein 7.

Abstract

The aim of the therapy in open tibial fractures grade III was to cover the bone with soft tissue and achieve healed fracture without persistent infection. Open tibial fractures grade IIIC with massive soft tissue damage require combined orthopaedic, vascular and plastic-reconstructive procedures. Negative-pressure wound therapy (NPWT), used in two consecutive cases with open fracture grade IIIC of the tibia diaphysis, healed extensive soft tissue defect with exposure of the bone. NPWT eventually allowed for wound closure by split skin graft within 21-25 days. Ilizarov external fixator combined with application of recombinant human bone morphogenetic protein-7 at the site of delayed union enhanced definitive bone healing within 16-18 months.

• Authors: Ireneusz Babiak
• Journal: International wound journal (Int Wound J) Vol. 11 Issue 5 Pg. 476-82 (Oct 2014) ISSN: 1742-481X [Electronic] England
• PMID: 23163923 (Publication Type: Case Reports, Journal Article)
• Copyright: © 2012 The Authors. International Wound Journal © 2012 Medicalhelplines.com Inc and John Wiley & Sons Ltd.

Chemical References

• Bone Morphogenetic Protein 7

Topics

• Adult
• Bone Morphogenetic Protein 7 (therapeutic use)
• External Fixators
• Female
• Fracture Fixation
• Fractures, Open (therapy)
• Humans
• Male
• Negative-Pressure Wound Therapy
• Retrospective Studies
• Soft Tissue Injuries (therapy)
• Tibial Fractures (therapy)
• Treatment Outcome
• Wound Healing