Abstract | BACKGROUND/AIMS: MATERIALS AND METHODS: Thirty-one patients with advanced and 27 patients with non-advanced liver disease were assessed. Patients were considered to have advanced liver disease when biopsy disclosed a fibrosis score of ≥4 according to Ishak or when imaging studies were indicative of cirrhosis. Virologic response, defined as achievement of undetectable hepatitis D virus RNA, was assessed at the end of treatment and end of 24 weeks of treatment-free follow-up. RESULTS: Patients with advanced disease had lower hepatitis D virus RNA levels and platelet counts (p=0.014 and p=0.0015, respectively). End of treatment and end of follow-up virologic responses in patients with advanced vs. non-advanced liver disease were similar (29% vs. 19% and 32% vs 23%). Proportion of adverse events did not differ between groups except that thrombocytopenia was noted more often in the advanced liver disease group. Further, four cases of clinically important adverse events including two cases of hepatic decompensation and one case of tuberculosis reactivation occurred in the advanced liver disease group. CONCLUSIONS:
|
Authors | Gökhan Kabaçam, George N Dalekos, Yılmaz Çakaloğlu, Kalliopi Zachou, Thomas Bock, Andreas Erhardt, Stefan Zeuzem, Fehmi Tabak, Kendal Yalçin, A Mithat Bozdayi, Hans P Dienes, Hakan Bozkaya, Michael Manns, Heiner Wedemeyer, Cihan Yurdaydin |
Journal | The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology
(Turk J Gastroenterol)
Vol. 23
Issue 5
Pg. 560-8
( 2012)
ISSN: 2148-5607 [Electronic] Turkey |
PMID | 23161302
(Publication Type: Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Antiviral Agents
- Interferon-alpha
- RNA, Viral
- Recombinant Proteins
- Polyethylene Glycols
- peginterferon alfa-2a
|
Topics |
- Adolescent
- Adult
- Aged
- Antiviral Agents
(administration & dosage)
- Biopsy
- Dose-Response Relationship, Drug
- Hepatitis D, Chronic
(complications, drug therapy, virology)
- Hepatitis Delta Virus
(genetics)
- Humans
- Interferon-alpha
(administration & dosage)
- Liver
(pathology)
- Liver Cirrhosis
(drug therapy, etiology, pathology)
- Middle Aged
- Polyethylene Glycols
(administration & dosage)
- RNA, Viral
(genetics)
- Recombinant Proteins
(administration & dosage)
- Treatment Outcome
- Young Adult
|