HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Neonatal short bowel syndrome as a model of intestinal failure: physiological background for enteral feeding.

Abstract
Intestinal failure (IF) is a well identified clinical condition, which is characterised by the reduction of functional gut capacity below the minimum needed for adequate digestion and absorption of nutrients for normal growth in children. Short bowel syndrome (SBS) is the leading cause of IF in neonates, infants and young children usually as a result of extensive intestinal resection during the neonatal period. Simultaneously maintaining optimal nutritional status and achieving intestinal adaptation is a clinical challenge in short bowel patients. Both growth and development of the child as well as gut adaptation should be considered synergistically as primary outcome parameters. Enteral nutrition (EN) can be introduced orally and/or by tube feeding (TF). Several controversies over nutritional treatment of children with SBS related intestinal failure remain. As reported from different centres around the world, most practices are more "experienced based" rather than "evidence based". This is partly due to the small number of patients with this condition. This review (based on a consensus) discusses the physiological principles and nutritional management, including the type of diet and route of delivery. Perspectives in optimizing intestinal adaptation and reducing the consequences of small intestinal bacterial overgrowth are also discussed.
AuthorsO Goulet, J Olieman, J Ksiazyk, J Spolidoro, D Tibboe, H Köhler, R Vural Yagci, J Falconer, G Grimble, R M Beattie
JournalClinical nutrition (Edinburgh, Scotland) (Clin Nutr) Vol. 32 Issue 2 Pg. 162-71 (Apr 2013) ISSN: 1532-1983 [Electronic] England
PMID23159212 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
CopyrightCopyright © 2012 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.
Chemical References
  • Dietary Carbohydrates
  • Dietary Fats
  • Dietary Fiber
  • Dietary Proteins
  • Fatty Acids, Unsaturated
Topics
  • Adaptation, Physiological
  • Child, Preschool
  • Diet
  • Dietary Carbohydrates (administration & dosage)
  • Dietary Fats (administration & dosage)
  • Dietary Fiber (administration & dosage)
  • Dietary Proteins (administration & dosage)
  • Enteral Nutrition
  • Fatty Acids, Unsaturated (administration & dosage)
  • Humans
  • Infant
  • Infant, Newborn
  • Intestine, Small (physiopathology)
  • Nutritional Status
  • Probiotics (administration & dosage)
  • Short Bowel Syndrome (diet therapy, physiopathology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: