Abstract | OBJECTIVE: METHODS: RESULTS: As assessed by H&E staining, a large number of degenerated and necrotic nerve cells were observed in corpus striatum in rats from in IN saline group. But in IN NGF group, the number of degenerated neurons was smaller than in IN NS group. Following OP exposure, the activity of AchE decreased in corpus striatum in both IN saline and IN NGF groups (0.46 ± 0.11 vs 0.35 ± 0.09 U/mg prot). No significant differences existed between two groups. But the concentrations of MDA in corpus striatum of IN NGF group rats reduced markedly by 25.14% (4.02 ± 0.85 vs 5.37 ± 1.33 nmol/mg prot) and the level of GSH increased sharply by 15.73% (52.82 ± 2.80 vs 45.64 ± 4.88 mg/g prot) as compared with IN saline group (P < 0.05). CONCLUSION: Intranasal dosing of NGF may improve neuropathology and protect rats against OP-induced oxidative damage in corpus striatum.
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Authors | Xin-ying Fan, Yun Li, Min-min Ma, Rui-bing Guo, Ge-lin Xu, Xin-feng Liu, Wu-sheng Zhu |
Journal | Zhonghua yi xue za zhi
(Zhonghua Yi Xue Za Zhi)
Vol. 92
Issue 33
Pg. 2366-9
(Sep 04 2012)
ISSN: 0376-2491 [Print] China |
PMID | 23158570
(Publication Type: English Abstract, Journal Article, Research Support, U.S. Gov't, Non-P.H.S.)
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Chemical References |
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Topics |
- Administration, Intranasal
- Animals
- Brain
(metabolism, pathology)
- Corpus Striatum
(drug effects, metabolism, pathology)
- Disease Models, Animal
- Female
- Male
- Nerve Growth Factor
(administration & dosage, pharmacology)
- Organophosphate Poisoning
(metabolism, pathology)
- Oxidative Stress
- Rats
- Rats, Sprague-Dawley
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