[An experimental study of the efficiency of cycloferon in the complex chemotherapy of generalized drug-resistant tuberculosis].

Abstract

The results of an experimental study of the efficiency of cycloferon included in a complex chemotherapy of generalized drug-resistant mycobacterium tuberculosis (MBT) are presented. It is established that cycloferon (3.6 mg/kg) produces a significant therapeutic effect, which is manifested by an increase in the lung clearance from MBT, a decrease in the spread of specific inflammation in the lungs, and the disappearance of MBT-induced alterations. In addition, activation of the signs of tension in the local immunity of lung tissues is observed as manifested by changes in the cellular composition of granulomas and more frequent detection of large lymphocytic and macrophage infiltration. The administration of cycloferon significantly increases the absorptive and digestive activity of phagocytosis by peritoneal macrophages, which has been inhibited during the development of experimental MBT infection.

• Authors: D S Sukhanov, T I Vinogradova, S N Demidik, A V El'kin, N V Zabolotnykh, S N Vasil'eva, M L Vitovskaia, M G Romantsov
• Journal: Eksperimental'naia i klinicheskaia farmakologiia (Eksp Klin Farmakol) Vol. 75 Issue 9 Pg. 32-6 ( 2012) ISSN: 0869-2092 [Print] Russia (Federation)
• PMID: 23156086 (Publication Type: Journal Article)

Chemical References

• Acridines
• Interferon Inducers
• 10-carboxymethyl-9-acridanone

Topics

• Acridines (pharmacology)
• Animals
• Disease Models, Animal
• Drug Therapy, Combination (methods)
• Interferon Inducers (pharmacology)
• Lung (microbiology, pathology)
• Male
• Mice
• Mycobacterium tuberculosis
• Tuberculosis, Multidrug-Resistant (drug therapy, microbiology, pathology)
• Tuberculosis, Pulmonary (drug therapy, microbiology, pathology)