Elevated coagulation factor VIII plasma activity in a patient with lymphangiosarcoma.

Abstract

A 72-year-old woman was referred to our hospital for palliative care. Fifteen years earlier, she had undergone total hysterectomy and radiotherapy for cervical cancer. One year before her referral, she visited a hospital due to a gait disturbance and was diagnosed with lymphangiosarcoma. The level of coagulation factor VIII plasma activity was >201% (normal range: 62-145%) and the immunohistochemical results were positive for factor VIII-related antigen in a tumor specimen. To the best of our knowledge, this is the first report of high coagulation factor VIII plasma activity in a patient with lymphangiosarcoma.

• Authors: Hiromichi Yamane, Nobuaki Ochi, Takayuki Tabayashi, Lu Lu, Tomoko Yamagishi, Yasumasa Monobe, Takehiro Tanaka, Eisei Kondoh, Nagio Takigawa
• Journal: Internal medicine (Tokyo, Japan) (Intern Med) Vol. 51 Issue 22 Pg. 3213-5 ( 2012) ISSN: 1349-7235 [Electronic] Japan
• PMID: 23154736 (Publication Type: Case Reports, Journal Article)

Chemical References

• von Willebrand Factor
• Factor VIII

Topics

• Aged
• Factor VIII (metabolism)
• Fatal Outcome
• Female
• Humans
• Immunohistochemistry
• Lymphangiosarcoma (blood, diagnosis, etiology, immunology)
• Lymphedema (complications)
• Thigh
• Uterine Cervical Neoplasms (complications)
• von Willebrand Factor (metabolism)