Carbamazepine-induced hypersensitivity syndrome in chronic schizophrenia.

Abstract

Drug-induced hypersensitivity syndrome is a clinically important issue. We report a case of carbamazepine-induced hypersensitivity syndrome in a 35-year-old schizophrenia patient. This patient had no previous food or medication allergy history and presented a negative test result of HLA-B*1502 genotype. After 19 days exposure of carbamazepine, high fever up to 39.4 °C, leucopenia (1670/mm3), proteinuria and bilateral lung field infiltration were developed. These clinically significant physical conditions resolved after discontinuing carbamazepine. The importance of genetic susceptibility other than HLA-B*1502 should not be overlooked in drug-induced hypersensitivity syndrome.

• Authors: Chan-Wei Pan, Chi-Hua Yu, Ding-Lieh Liao
• Journal: General hospital psychiatry (Gen Hosp Psychiatry) 2013 Sep-Oct Vol. 35 Issue 5 Pg. 575.e9-10 ISSN: 1873-7714 [Electronic] United States
• PMID: 23153842 (Publication Type: Case Reports, Journal Article)
• Copyright: Copyright © 2013 Elsevier Inc. All rights reserved.

Chemical References

• Antimanic Agents
• Carbamazepine

Topics

• Adult
• Antimanic Agents (adverse effects, therapeutic use)
• Carbamazepine (adverse effects, therapeutic use)
• Drug Hypersensitivity Syndrome (etiology)
• Female
• Humans
• Risk Factors
• Schizophrenia (drug therapy)