Abstract | BACKGROUND: Right ventricular (RV) dysfunction (RVD) is the most frequent cause of death in patients with pulmonary arterial hypertension. Although abnormal energy substrate use has been implicated in the development of chronic left heart failure, data describing such metabolic remodeling in RVD remain incomplete. Thus, we sought to characterize metabolic gene expression changes and mitochondrial dysfunction in functional and dysfunctional RV hypertrophy. METHODS AND RESULTS: CONCLUSIONS:
|
Authors | Jose Gomez-Arroyo, Shiro Mizuno, Karol Szczepanek, Benjamin Van Tassell, Ramesh Natarajan, Cristobal G dos Remedios, Jennifer I Drake, Laszlo Farkas, Donatas Kraskauskas, Dayanjan S Wijesinghe, Charles E Chalfant, John Bigbee, Antonio Abbate, Edward J Lesnefsky, Harm J Bogaard, Norbert F Voelkel |
Journal | Circulation. Heart failure
(Circ Heart Fail)
Vol. 6
Issue 1
Pg. 136-44
(Jan 2013)
ISSN: 1941-3297 [Electronic] United States |
PMID | 23152488
(Publication Type: Comparative Study, Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)
|
Topics |
- Animals
- Disease Models, Animal
- Familial Primary Pulmonary Hypertension
- Heart Failure
(etiology, genetics, physiopathology)
- Hypertension, Pulmonary
(complications, genetics, metabolism)
- Hypertrophy, Right Ventricular
(complications, genetics, metabolism)
- Male
- Mitochondria, Heart
(genetics, metabolism)
- Mitochondrial Turnover
(genetics)
- Myocytes, Cardiac
(metabolism)
- Oxidation-Reduction
- Rats
- Rats, Sprague-Dawley
- Ventricular Remodeling
(genetics)
|
|
Join CureHunter, for free Research Interface BASIC access!
Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease.
Find out why thousands of doctors, pharma researchers and patient activists
around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!
|