Dextromethorphan for treatment of complex partial seizures.

Abstract

We performed a double-blind, crossover, add-on study of the antitussive agent dextromethorphan (DM 120 mg/d) as therapy for seizures on 9 patients suffering from severe complex partial seizures. DM had no significant influence on key laboratory values, nor on anticonvulsant drug levels. Side effects were negligible. Complex partial seizure frequency increased 25% during the DM arm of the study, although this increase was not clinically significant.

• Authors: R S Fisher, B J Cysyk, R P Lesser, M J Pontecorvo, J T Ferkany, P R Schwerdt, J Hart, B Gordon
• Journal: Neurology (Neurology) Vol. 40 Issue 3 Pt 1 Pg. 547-9 (Mar 1990) ISSN: 0028-3878 [Print] United States
• PMID: 2314601 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anticonvulsants
• Levorphanol
• Dextromethorphan

Topics

• Adult
• Anticonvulsants (therapeutic use)
• Dextromethorphan (therapeutic use)
• Double-Blind Method
• Drug Interactions
• Epilepsy, Temporal Lobe (drug therapy)
• Female
• Humans
• Levorphanol (analogs & derivatives)
• Male
• Middle Aged
• Neuropsychological Tests
• Pilot Projects
• Random Allocation