Abstract | BACKGROUND: METHODS: Plasma gelsolin levels of 132 patients and 68 healthy controls were quantified by enzyme-linked immunosorbent assay. Its correlation with 6-month mortality and unfavorable outcome (modified Rankin Scale score>2) was analyzed. RESULTS: Forty-six patients (34.9%) died and 79 patients (59.9%) had an unfavorable outcome at 6 months. Upon admission, plasma gelsolin level was significantly lower in patients than healthy controls. Plasma gelsolin level was highly correlated with National Institutes of Health Stroke Scale score. A forward stepwise logistic regression selected plasma gelsolin level as an independent predictor for 6-month mortality and unfavorable outcome of patients. A receiver operating characteristic curve analysis showed that plasma gelsolin level had high area under curve for predicting 6-month clinical outcomes. The prognostic value of gelsolin was similar to that of National Institutes of Health Stroke Scale score for 6-month clinical outcomes. Gelsolin improved the prognostic value of National Institutes of Health Stroke Scale score for 6-month unfavorable outcome, but not for 6-month mortality. CONCLUSION:
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Authors | Dong-Qing Zhao, Ke Wang, Hai-Dong Zhang, Yu-Jian Li |
Journal | Clinica chimica acta; international journal of clinical chemistry
(Clin Chim Acta)
Vol. 415
Pg. 202-6
(Jan 16 2013)
ISSN: 1873-3492 [Electronic] Netherlands |
PMID | 23142649
(Publication Type: Journal Article)
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Copyright | Copyright © 2012 Elsevier B.V. All rights reserved. |
Chemical References |
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Topics |
- Aged
- Area Under Curve
- Biomarkers
(blood)
- Cerebral Hemorrhage
(blood, diagnosis, mortality)
- Enzyme-Linked Immunosorbent Assay
- Female
- Gelsolin
(blood)
- Humans
- Logistic Models
- Male
- Middle Aged
- Prognosis
- ROC Curve
- Severity of Illness Index
- Survival Analysis
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