Midterm outcome of risedronate therapy for patients with Paget's disease of bone in the central part of Japan.

Abstract

Although Paget's disease of bone (PDB) is common in western countries, it is extremely rare in Asian ones including Japan. Recently, oral risedronate (17.5 mg once daily) was approved in Japan as a treatment of PDB besides calcitonin and etidronate. However, there are few data regarding the efficacy of this agent, dose for patients with PDB in Japan, or the durability of its effect. The purpose of this study was to evaluate the midterm outcome of oral risedronate (17.5 mg once daily) for patients with PDB in Japan. Seventeen patients with PDB were treated with risedronate (17.5 mg once daily) for 8 weeks. Efficacy and its durability were accessed based on serum total alkaline phosphatase (ALP) and symptoms. Risedronate effectively suppressed bone turnover evaluated with serum total ALP in all patients. In 8 of 10 patients with bone pain, risedronate reduced the pain. On the other hand, tinnitus and hearing loss did not disappear but somewhat improved. None of the patients suffered severe complications. Seven of 17 patients required readministration of oral bisphosphonate (risedronate, six; alendronate, one) due to elevated total ALP at 27 months (mean ranging from 9 to 39 months) after the initial administration of risedronate. Treatment of oral risedronate (17.5 mg once daily) for 8 weeks is safe and effective for patients with PDB in Japan. However, the durability of its effect is limited in some patients.

• Authors: Yoshihiro Nishida, Yoshihisa Yamada, Satoshi Tsukushi, Hideshi Sugiura, Hiroshi Urakawa, Naoki Ishiguro
• Journal: Clinical rheumatology (Clin Rheumatol) Vol. 32 Issue 2 Pg. 241-5 (Feb 2013) ISSN: 1434-9949 [Electronic] Germany
• PMID: 23138882 (Publication Type: Clinical Trial, Clinical Trial, Phase III, Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)

Chemical References

• Bone Density Conservation Agents
• Alkaline Phosphatase
• Risedronic Acid
• Etidronic Acid

Topics

• Adult
• Aged
• Aged, 80 and over
• Alkaline Phosphatase (blood)
• Bone Density Conservation Agents (administration & dosage, adverse effects)
• Bone and Bones (drug effects, metabolism)
• Etidronic Acid (administration & dosage, adverse effects, analogs & derivatives)
• Female
• Follow-Up Studies
• Humans
• Japan
• Male
• Middle Aged
• Osteitis Deformans (drug therapy, metabolism)
• Prospective Studies
• Risedronic Acid
• Treatment Outcome