Abstract | BACKGROUND AND OBJECTIVE: METHODS: RESULTS: H. pylori was positive in 98 (60.5%) patients and 38 of these patients were Cag A positive. Serum pepsinogen level was significantly lower in patients with autoimmune atrophic gastritis compared to the patients with non-atrophic chronic gastritis (p<0.001), intestinal metaplasia (P<0.001) and dysplasia (P=0.002). Mean serum gastrin was 1209.6±268.48 pg/mL in patients with autoimmune atrophic gastritis and 234.95±184.018 pg/mL in patients with chronic non- atrophic gastritis. Mean toll-like receptor-4 level was 0.56±0.098 ng/mL in patient with dysplasia, and this value was higher compared to patients with chronic non- atrophic gastritis (P=0.007), autoimmune atrophic gastritis (P=0.003) and intestinal metaplasia (P=0.006). Interleukin-1 Beta level was significantly lower in patients with dysplasia compared to patients with chronic non- atrophic gastritis (P=0.034). CONCLUSIONS: Serum pepsinogens, serum gastrin and H. pylori Cag A status are important tests in detecting gastric precancerous lesions. However, toll-like receptor-4 may be a sensitive test to differentiate the patients with dysplasia from the other precancerous gastric lesions. Non-invasive tests are sensitive in the diagnosis of gastric precancerous lesions.
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Authors | Mustafa Yakut, Necati Örmeci, Harun Erdal, Onur Keskin, Zihni Karayel, Hüseyin Tutkak, Irfan Soykan |
Journal | Clinics and research in hepatology and gastroenterology
(Clin Res Hepatol Gastroenterol)
Vol. 37
Issue 3
Pg. 302-11
(Jun 2013)
ISSN: 2210-741X [Electronic] France |
PMID | 23137754
(Publication Type: Journal Article)
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Copyright | Copyright © 2012. Published by Elsevier Masson SAS. |
Chemical References |
- Antigens, Bacterial
- Bacterial Proteins
- Biomarkers
- Gastrins
- Interleukin-1beta
- TLR4 protein, human
- Toll-Like Receptor 4
- Vascular Endothelial Growth Factor A
- cagA protein, Helicobacter pylori
- gastrin 17
- Pepsinogen C
- Pepsinogen A
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Topics |
- Adult
- Aged
- Antigens, Bacterial
(blood)
- Bacterial Proteins
(blood)
- Biomarkers
(blood)
- Female
- Gastrins
(blood)
- Gastritis
(blood, pathology)
- Helicobacter pylori
(isolation & purification)
- Humans
- Interleukin-1beta
(blood)
- Male
- Metaplasia
(blood, pathology)
- Middle Aged
- Pepsinogen A
(blood)
- Pepsinogen C
(blood)
- Precancerous Conditions
(blood, diagnosis)
- Sensitivity and Specificity
- Stomach
(pathology)
- Stomach Neoplasms
(blood, pathology)
- Toll-Like Receptor 4
(blood)
- Vascular Endothelial Growth Factor A
(blood)
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