Abstract | OBJECTIVE: METHODS:
Clocortolone pivalate 0.01% cream was applied to affected facial skin in subjects presenting with seborrheic dermatitis, contact dermatitis, atopic dermatitis, or psoriasis. Application was completed three times daily for 21 days. Assessments of erythema, edema, transudation, lichenification, scaling, pruritus and/or pain were completed at baseline and Days 4, 7, 14, and 21. Overall therapeutic response was assessed at all follow-up visits. Forty-nine subjects were entered, ranging in age from 1 month to 88 years of age. Thirty-eight subjects completed the studies, with 11 subjects lost to follow-up after the first visit. Individuals between the ages of 13 and 19 years were pre-emptively excluded to avoid potential application of a corticosteroid to acne-affected or acne-prone skin. RESULTS: Treatment with clocortolone pivalate 0.1% cream resulted in decreases in erythema, edema, transudation, lichenification, scaling, and pruritus/ pain in 76% of treated study subjects. The overall therapeutic response in approximately two-thirds of the subjects (68%) was rated as good to excellent. There were 7 adverse events noted over the course of the study that were judged to be related to treatment, all of which were cutaneous and localized to the site of application ( acneiform eruptions, burning, and folliculitis). CONCLUSION:
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Authors | Leon H Kircik, James Q Del Rosso |
Journal | Journal of drugs in dermatology : JDD
(J Drugs Dermatol)
Vol. 11
Issue 10
Pg. 1194-8
(Oct 2012)
ISSN: 1545-9616 [Print] United States |
PMID | 23134984
(Publication Type: Clinical Trial, Journal Article)
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Chemical References |
- Glucocorticoids
- Fluocortolone
- clocortolone pivalate
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Child
- Child, Preschool
- Dermatitis, Atopic
(complications, drug therapy)
- Dermatitis, Contact
(complications, drug therapy)
- Dermatitis, Seborrheic
(complications, drug therapy)
- Edema
(drug therapy, etiology)
- Erythema
(drug therapy, etiology)
- Exudates and Transudates
(drug effects)
- Facial Dermatoses
(complications, drug therapy)
- Female
- Fluocortolone
(adverse effects, analogs & derivatives, therapeutic use)
- Glucocorticoids
(adverse effects, therapeutic use)
- Humans
- Infant
- Male
- Middle Aged
- Pain
(drug therapy, etiology)
- Pruritus
(drug therapy, etiology)
- Psoriasis
(complications, drug therapy)
- Skin Cream
- Treatment Outcome
- Young Adult
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