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Darier-White disease in siblings responding to isotretinoin.

Abstract
Darier-White disease (keratosis follicularis) is a rare disorder of keratinization involving the epidermis, mucous membranes, and nails. It is said to occur as a result of mutation in the ATP2A2 gene located on chromosome 12q23-24.1. In this article we present the case of two brothers with exacerbations of Darier-White disease who responded very well to systemic retinoids without any side effects within 2 weeks of commencing treatment.
AuthorsRamesh M Bhat, Krithi Raviraj Ullal, Anita Caroline Pinto, D Sukumar
JournalIndian dermatology online journal (Indian Dermatol Online J) Vol. 1 Issue 1 Pg. 18-20 (Jul 2010) ISSN: 2229-5178 [Print] India
PMID23130186 (Publication Type: Case Reports)

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