Abstract | OBJECTIVE: METHODS: A retrospective cohort study was made of 50 consecutive cases of children and adolescents aged 16 years or less with Burkitt's lymphoma admitted between January 1981 and December 2007. Prognostic factors associated with death were evaluated using the Kaplan-Meier method and compared by the two-tailed log-rank test. RESULTS: The median age at diagnosis was 4.7 years. Most patients had abdominal tumors (66.7%) and advanced disease (68.9%) at diagnosis. Thirty-eight patients (84.4%) achieved complete clinical remission and 33 (73.3%) were alive at the first remission. Twelve children (26.7%) died. The median follow-up was 35 months with the probability of overall survival being 73% (89.2% and 35.7% for patients with uric acid < 7 mg/dL and ≥ 7.0 mg/dL, respectively - p-value < 0.001). Uric acid was the only significant prognostic factor at diagnosis. CONCLUSION: Our findings confirm the favorable prognosis of children with Burkitt's lymphoma even when treated with intermediate doses of methotrexate (500 mg/m2). Survival was significantly lower for individuals with concentrations of uric acid > 7 mg/dL.
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Authors | Keyla Christy Christine Mendes Sampaio Cunha, Maria Christina Lopes Araujo Oliveira, Ana Cecília Silva Gomes, Lucia Porto Fonseca de Castro, Marcos Borato Viana |
Journal | Revista brasileira de hematologia e hemoterapia
(Rev Bras Hematol Hemoter)
Vol. 34
Issue 5
Pg. 361-6
( 2012)
ISSN: 1806-0870 [Electronic] Brazil |
PMID | 23125545
(Publication Type: Journal Article)
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