Abstract |
Onychomycosis, a fungal infection of the finger or toenails, is predominantly caused by Trichophyton rubrum. Treatment is difficult due to high recurrence rates and problems with treatment compliance. For these reasons, alternative therapies are needed. Here we describe the photoactivation of Rose Bengal (RB) using a green laser (λ = 532 nm) at fluences of 68, 133 and 228 J/cm(2) , and assess its fungicidal activity on T. rubrum spore suspensions. A 140 µM RB solution was able to induce a fungicidal effect on T. rubrum when photosensitized with the fluence of 228 J/cm(2) . RB photosensitization using a green laser provides a potential novel treatment for T. rubrum infections.
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Authors | Leah Cronin, Michelle Moffitt, Damia Mawad, Oliver C Morton, Antonio Lauto, Colin Stack |
Journal | Journal of biophotonics
(J Biophotonics)
Vol. 7
Issue 6
Pg. 410-7
(Jun 2014)
ISSN: 1864-0648 [Electronic] Germany |
PMID | 23125143
(Publication Type: Journal Article)
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Copyright | Copyright © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. |
Chemical References |
- Photosensitizing Agents
- Rose Bengal
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Topics |
- Darkness
- Dose-Response Relationship, Drug
- Lasers
- Optical Phenomena
- Photochemotherapy
- Photosensitizing Agents
(pharmacology)
- Rose Bengal
(pharmacology)
- Trichophyton
(drug effects, radiation effects)
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