HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

An in vitro study of the photodynamic effect of rose bengal on Trichophyton rubrum.

Abstract
Onychomycosis, a fungal infection of the finger or toenails, is predominantly caused by Trichophyton rubrum. Treatment is difficult due to high recurrence rates and problems with treatment compliance. For these reasons, alternative therapies are needed. Here we describe the photoactivation of Rose Bengal (RB) using a green laser (λ = 532 nm) at fluences of 68, 133 and 228 J/cm(2) , and assess its fungicidal activity on T. rubrum spore suspensions. A 140 µM RB solution was able to induce a fungicidal effect on T. rubrum when photosensitized with the fluence of 228 J/cm(2) . RB photosensitization using a green laser provides a potential novel treatment for T. rubrum infections.
AuthorsLeah Cronin, Michelle Moffitt, Damia Mawad, Oliver C Morton, Antonio Lauto, Colin Stack
JournalJournal of biophotonics (J Biophotonics) Vol. 7 Issue 6 Pg. 410-7 (Jun 2014) ISSN: 1864-0648 [Electronic] Germany
PMID23125143 (Publication Type: Journal Article)
CopyrightCopyright © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Chemical References
  • Photosensitizing Agents
  • Rose Bengal
Topics
  • Darkness
  • Dose-Response Relationship, Drug
  • Lasers
  • Optical Phenomena
  • Photochemotherapy
  • Photosensitizing Agents (pharmacology)
  • Rose Bengal (pharmacology)
  • Trichophyton (drug effects, radiation effects)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: