Efficacy and safety of thymoglobulin and basiliximab in kidney transplant patients at high risk for acute rejection and delayed graft function.

Abstract

OBJECTIVES:

To compare the efficacy and safety of thymoglobulin compared with basiliximab in patients who had kidney transplants and are at high risk for acute rejection and delayed graft function.

MATERIALS AND METHODS:

A retrospective review of patients who had 1 or more risk factors for acute rejection and delayed graft function and who were given either thymoglobulin or basiliximab for induction therapy. Incidences of acute rejection, antibody-treated acute rejection, delayed graft function, chronic rejection, cancer, infection, leucopenia, and thrombocytopenia were compared between thymoglobulin and basiliximab groups. Serum creatinine levels within 1 year and long-term graft and patient survival also were compared.

RESULTS:

A total of 327 patients were included. Incidences of acute rejection, antibody-treated acute rejection, delayed graft function, and chronic rejection were significantly lower in the thymoglobulin group than in the basiliximab group (P < .05). Serum creatinine levels were lower in the thymoglobulin group on postoperative days 7, 14, and 30 (P < .05). There were no statistically significant differences regarding long-term graft and patient survival, cancer, or total infection rate between the groups. Incidences of Cytomegalovirus infection, leucopenia, and thrombocytopenia were significantly higher in the thymoglobulin group (P < .05).

CONCLUSIONS:

Thymoglobulin may improve short-term outcomes, compared with basiliximab, in patients who had kidney transplants and are at high risk for acute rejection and delayed graft function. However, long-term outcomes are similar with thymoglobulin and basiliximab.

• Authors: Guodong Chen, Jingli Gu, Jiang Qiu, Changxi Wang, Jiguang Fei, Suxiong Deng, Jun Li, Gang Huang, Qian Fu, Lizhong Chen
• Journal: Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation (Exp Clin Transplant) Vol. 11 Issue 4 Pg. 310-4 (Aug 2013) ISSN: 2146-8427 [Electronic] Turkey
• PMID: 23121641 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antibodies, Monoclonal
• Antilymphocyte Serum
• Biomarkers
• Immunosuppressive Agents
• Recombinant Fusion Proteins
• Basiliximab
• Creatinine
• thymoglobulin

Topics

• Acute Disease
• Adult
• Antibodies, Monoclonal (adverse effects, therapeutic use)
• Antilymphocyte Serum (adverse effects, therapeutic use)
• Basiliximab
• Biomarkers (blood)
• Chi-Square Distribution
• China (epidemiology)
• Chronic Disease
• Creatinine (blood)
• Delayed Graft Function (blood, epidemiology, mortality, prevention & control)
• Female
• Graft Rejection (blood, epidemiology, immunology, mortality, prevention & control)
• Graft Survival (drug effects)
• Humans
• Immunosuppressive Agents (adverse effects, therapeutic use)
• Incidence
• Kaplan-Meier Estimate
• Kidney Transplantation (adverse effects, mortality)
• Male
• Middle Aged
• Recombinant Fusion Proteins (adverse effects, therapeutic use)
• Retrospective Studies
• Risk Factors
• Time Factors
• Treatment Outcome