Abstract | PURPOSE: Monomeric IgE molecules, when bound to the high-affinity receptor, exhibit a vast heterogeneity in their ability to induce survival promotion and cytokine production in mast cells. At one end of this spectrum, highly cytokinergic (HC) IgEs can induce potent survival promotion, degranulation, cytokine production, migration, etc., whereas at the other end, poorly cytokinergic (PC) IgEs can do so inefficiently. In this study, we investigated whether IgEs recognize autoantigens and whether IgEs' binding of autoantigens correlates with difference s in HC versus PC properties. METHODS: RESULTS: CONCLUSIONS: The results show that most HC, but not PC, IgEs exhibit polyreactivity to autoantigens, supporting the autoimmune mechanism in the pathogenesis of atopic dermatitis.
|
Authors | Jun-Ichi Kashiwakura, Yoshimichi Okayama, Masutaka Furue, Kenji Kabashima, Shinji Shimada, Chisei Ra, Reuben P Siraganian, Yuko Kawakami, Toshiaki Kawakami |
Journal | Allergy, asthma & immunology research
(Allergy Asthma Immunol Res)
Vol. 4
Issue 6
Pg. 332-40
(Nov 2012)
ISSN: 2092-7363 [Electronic] Korea (South) |
PMID | 23115729
(Publication Type: Journal Article)
|