Abstract | BACKGROUND: METHODS AND RESULTS: TP gene expression was analyzed by real-time quantitative PCR in tumor and mucosa samples from 254 patients. TP gene expression in tumors correlated with lymph node staging, with higher expression relating to a higher number of positive nodes and a worse N-stage. Higher TP expression was also associated with a worse histological tumor grade. Patients with rectal cancer had significantly higher TP expression in mucosa and tumors compared with patients having colon cancer. CONCLUSION: Higher intratumoral TP expression appears to be related to a worse N stage, and thus, with a worse prognosis. TP gene expression measured in a preoperative biopsy could be of interest in preoperative staging.
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Authors | Elinor B Lindskog, Yvonne Wettergren, Elisabeth Odin, Bengt Gustavsson, Kristoffer Derwinger |
Journal | Clinical Medicine Insights. Oncology
(Clin Med Insights Oncol)
Vol. 6
Pg. 347-53
( 2012)
ISSN: 1179-5549 [Electronic] United States |
PMID | 23115484
(Publication Type: Journal Article)
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