Total ginsenosides of Radix Ginseng modulates tricarboxylic acid cycle protein expression to enhance cardiac energy metabolism in ischemic rat heart tissues.

Abstract	To elucidate the underlying mechanism of cardio-protective activity of the total ginsenosides (TGS) of Radix Ginseng, proteomic analysis using two-dimensional gel electrophoresis (2-DE) and MALDI-TOF-TOF-MS techniques was employed for identifying the underlying targets of TGS on improvement of the energy metabolism of isolated rat heart tissues perfused in Langendorff system under ischemia-reperfusion injury conditions. The image analysis results revealed 11 differentially expressed proteins in the TGS-treated heart tissues; these proteins, including LDHB and ODP-2, were found to be closely related to the function of tricarboxylic acid (TCA) cycle that plays pivotal roles in cardiac energy metabolism. It is thus concluded that improvement of cardiac energy metabolism via activating proteins in TCA cycle could be the major action pathway and targets of TGS activity against rat heart tissue injury.
Authors	Jing-Rong Wang, Hua Zhou, Xiao-Qin Yi, Zhi-Hong Jiang, Liang Liu
Journal	Molecules (Basel, Switzerland) (Molecules) Vol. 17 Issue 11 Pg. 12746-57 (Oct 29 2012) ISSN: 1420-3049 [Electronic] Switzerland
PMID	23108293 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Cardiotonic Agents Drugs, Chinese Herbal Ginsenosides Microtubule-Associated Proteins Muscle Proteins Proteome Oxidoreductases Adenine Phosphoribosyltransferase PARK7 protein, rat Protein Deglycase DJ-1
Topics	Adenine Phosphoribosyltransferase (genetics, metabolism) Animals Cardiotonic Agents (pharmacology) Citric Acid Cycle Drugs, Chinese Herbal (pharmacology) Energy Metabolism (drug effects) Gene Expression (drug effects) Ginsenosides (pharmacology) In Vitro Techniques Male Microtubule-Associated Proteins (genetics, metabolism) Muscle Proteins (genetics, metabolism) Myocardial Ischemia (drug therapy, metabolism) Myocardial Reperfusion Injury (metabolism, prevention & control) Myocardium (enzymology, metabolism) Oxidoreductases (genetics, metabolism) Panax (chemistry) Plant Roots (chemistry) Protein Deglycase DJ-1 Proteome (genetics, metabolism) Rats Rats, Sprague-Dawley

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