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The effect of intraarterial high-dose cisplatin on lymph nodes in oral and oropharyngeal cancer.

AbstractAIM OF STUDY:
To assess the effect of strictly local treatment [intraarterial chemotherapy (iaCHT) with high-dose cisplatin and parallel neutralization] in the primary oral and oropharyngeal cancer (OOSCC) on the dependent cervical lymph nodes.
PATIENTS AND METHODS:
Seventeen consecutive patients with OOSCC and clinically positive necks underwent a prospective blinded comparison of two pre-surgical fluor18-deoxyglucose (FDG)-positron emission tomography (PET) examinations: baseline examination 1 week before and follow-up examination 3 weeks after iaCHT. Maximal standardized uptake (SUVmax) values of lymph nodes were measured and compared with each other and histopathology.
RESULTS:
The SUVmax value of the primary and all neck lymph nodes with uptake decreased significantly. Twelve/17 patients having metastases revealed significant decrease (P = 0.03), and benign lymph nodes showed non-significant decrease of the SUVmax. All neck lymph nodes with uptake and nodal metastases showed a significant reduction (P = 0.004) of standard uptake values (SUV).
CONCLUSION:
A regional effect of intraarterial cisplatin is proven. To date, it is not clear whether this is due to decreasing inflammatory reaction or a translymphatic anti-neoplastic effect.
AuthorsA F Kovács, N Döbert, K Engels
JournalIndian journal of cancer (Indian J Cancer) 2012 Apr-Jun Vol. 49 Issue 2 Pg. 230-5 ISSN: 1998-4774 [Electronic] India
PMID23107976 (Publication Type: Journal Article)
Chemical References
  • Antineoplastic Agents
  • Radiopharmaceuticals
  • Fluorodeoxyglucose F18
  • Cisplatin
Topics
  • Aged
  • Aged, 80 and over
  • Antineoplastic Agents (therapeutic use)
  • Cisplatin (therapeutic use)
  • Dose-Response Relationship, Drug
  • Female
  • Fluorodeoxyglucose F18
  • Follow-Up Studies
  • Humans
  • Injections, Intra-Arterial
  • Lymph Nodes (diagnostic imaging, drug effects, pathology)
  • Lymphatic Metastasis
  • Male
  • Middle Aged
  • Mouth Neoplasms (drug therapy, pathology)
  • Neoplasm Staging
  • Oropharyngeal Neoplasms (drug therapy, pathology)
  • Positron-Emission Tomography
  • Prognosis
  • Prospective Studies
  • Radiopharmaceuticals

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