Abstract | AIM OF STUDY: To assess the effect of strictly local treatment [intraarterial chemotherapy (iaCHT) with high-dose cisplatin and parallel neutralization] in the primary oral and oropharyngeal cancer (OOSCC) on the dependent cervical lymph nodes. PATIENTS AND METHODS: Seventeen consecutive patients with OOSCC and clinically positive necks underwent a prospective blinded comparison of two pre-surgical fluor18-deoxyglucose (FDG)-positron emission tomography (PET) examinations: baseline examination 1 week before and follow-up examination 3 weeks after iaCHT. Maximal standardized uptake (SUVmax) values of lymph nodes were measured and compared with each other and histopathology. RESULTS: The SUVmax value of the primary and all neck lymph nodes with uptake decreased significantly. Twelve/17 patients having metastases revealed significant decrease (P = 0.03), and benign lymph nodes showed non-significant decrease of the SUVmax. All neck lymph nodes with uptake and nodal metastases showed a significant reduction (P = 0.004) of standard uptake values (SUV). CONCLUSION: A regional effect of intraarterial cisplatin is proven. To date, it is not clear whether this is due to decreasing inflammatory reaction or a translymphatic anti-neoplastic effect.
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Authors | A F Kovács, N Döbert, K Engels |
Journal | Indian journal of cancer
(Indian J Cancer)
2012 Apr-Jun
Vol. 49
Issue 2
Pg. 230-5
ISSN: 1998-4774 [Electronic] India |
PMID | 23107976
(Publication Type: Journal Article)
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Chemical References |
- Antineoplastic Agents
- Radiopharmaceuticals
- Fluorodeoxyglucose F18
- Cisplatin
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Topics |
- Aged
- Aged, 80 and over
- Antineoplastic Agents
(therapeutic use)
- Cisplatin
(therapeutic use)
- Dose-Response Relationship, Drug
- Female
- Fluorodeoxyglucose F18
- Follow-Up Studies
- Humans
- Injections, Intra-Arterial
- Lymph Nodes
(diagnostic imaging, drug effects, pathology)
- Lymphatic Metastasis
- Male
- Middle Aged
- Mouth Neoplasms
(drug therapy, pathology)
- Neoplasm Staging
- Oropharyngeal Neoplasms
(drug therapy, pathology)
- Positron-Emission Tomography
- Prognosis
- Prospective Studies
- Radiopharmaceuticals
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