Screening of VCP mutations in Chinese amyotrophic lateral sclerosis patients.

Abstract

Mutations in valosin-containing protein (VCP) gene have been recently found in familial and sporadic amyotrophic lateral sclerosis (ALS). To define the frequency of VCP mutations in ALS patients in Chinese population, we sequenced all 17 exons of the VCP gene in a cohort of both familial and sporadic ALS patients of Chinese origin. No nonsynonymous coding variants were identified. This indicates that VCP mutations are not a common cause of familial or sporadic ALS in Chinese population.

• Authors: Zhang-Yu Zou, Ming-Sheng Liu, Xiao-Guang Li, Li-Ying Cui
• Journal: Neurobiology of aging (Neurobiol Aging) Vol. 34 Issue 5 Pg. 1519.e3-4 (May 2013) ISSN: 1558-1497 [Electronic] United States
• PMID: 23102936 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2013 Elsevier Inc. All rights reserved.

Chemical References

• Cell Cycle Proteins
• Genetic Markers
• Adenosine Triphosphatases
• VCP protein, human
• Valosin Containing Protein

Topics

• Adenosine Triphosphatases (genetics)
• Amyotrophic Lateral Sclerosis (epidemiology, genetics)
• Cell Cycle Proteins (genetics)
• China (epidemiology)
• Female
• Genetic Markers (genetics)
• Genetic Predisposition to Disease (epidemiology, genetics)
• Genetic Testing (statistics & numerical data)
• Humans
• Male
• Middle Aged
• Mutation (genetics)
• Polymorphism, Single Nucleotide (genetics)
• Prevalence
• Risk Factors
• Valosin Containing Protein