Preliminary evaluation of the safety and efficacy of standard intravenous immunoglobulins in pregnant women with primary cytomegalovirus infection.

Abstract

Hyperimmune globulins were reported to prevent and treat fetal cytomegalovirus (CMV) infection during pregnancy. Here, we report that infusions of standard human intravenous immunoglobulin significantly increase CMV IgG titers and avidity indexes in pregnant women, paving the way to their use for passive transfer of maternal CMV humoral immunity to fetuses. Preliminary data on perinatal outcomes of the first 67 newborns are encouraging.

• Authors: Ennio Polilli, Giustino Parruti, Francesca D'Arcangelo, Elisa Tracanna, Luigi Clerico, Vincenzo Savini, Francesco D'Antonio, Maurizio Rosati, Lamberto Manzoli, Domenico D'Antonio, Giovanni Nigro
• Journal: Clinical and vaccine immunology : CVI (Clin Vaccine Immunol) Vol. 19 Issue 12 Pg. 1991-3 (Dec 2012) ISSN: 1556-679X [Electronic] United States
• PMID: 23100477 (Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Immunoglobulins, Intravenous

Topics

• Adult
• Cytomegalovirus Infections (therapy)
• Female
• Humans
• Immunoglobulins, Intravenous (therapeutic use)
• Immunotherapy (methods)
• Infusions, Intravenous
• Pregnancy
• Pregnancy Complications, Infectious (therapy)
• Pregnant Women