Magnetic resonance imaging-guided focused ultrasound treatment of pedunculated subserosal uterine fibroids: a preliminary report.

Abstract

PURPOSE:

To evaluate magnetic resonance (MR) imaging-guided focused ultrasound (US) as a treatment for pedunculated subserosal fibroids.

MATERIALS AND METHODS:

Over a 2-year period (March 2007 to March 2009), 135 women with symptomatic uterine fibroids were treated in the authors' institution using MR imaging-guided focused US. Of these women, nine (mean age, 39 years; range, 25-47 y) had a single pedunculated subserosal fibroid. During treatment, these pedunculated fibroids were targeted, while sparing the stalk connection between the fibroid and the uterus. Contrast-enhanced T1-weighted MR images were obtained immediately after the treatment to measure the nonperfused volume (NPV) ratio and to check stalk viability. Changes in tumor volume, diameter of the stalk, patient symptoms and adverse events were evaluated 6 months after treatment.

RESULTS:

The volume of the treated fibroids (n=9) ranged from 79-380cm(3) (mean, 198cm(3)), and NPV ratio ranged from 45%-80% (mean, 67%). MR imaging follow-up at 6 months showed a 14%-48% (mean, 30%) reduction in the volume of the treated fibroids (P =.008). In all cases, the pedunculated subserosal fibroids remained connected to the uterus with a 13% average decrease in the mean diameter of the stalks (from 3.5 to 3.0cm; P=.008). Eight of nine patients (89%) reported improvement in bulk-related fibroid symptoms after treatment.

CONCLUSIONS:

The results of this preliminary study suggest that MR imaging-guided focused US may be a safe and effective treatment for pedunculated subserosal fibroids. Larger prospective studies with longer follow-up are needed to confirm the suitability of MR imaging-guided focused US to treat this type of fibroid.

• Authors: Hyun Park, Sang-Wook Yoon, Kyoung-Ah Kim, Dae Jung Kim, Sang-Geun Jung
• Journal: Journal of vascular and interventional radiology : JVIR (J Vasc Interv Radiol) Vol. 23 Issue 12 Pg. 1589-93 (Dec 2012) ISSN: 1535-7732 [Electronic] United States
• PMID: 23099002 (Publication Type: Clinical Trial, Journal Article)
• Copyright: Copyright © 2012 SIR. Published by Elsevier Inc. All rights reserved.

Topics

• Adult
• Female
• High-Intensity Focused Ultrasound Ablation (methods)
• Humans
• Leiomyoma (pathology, therapy)
• Magnetic Resonance Imaging, Interventional (methods)
• Middle Aged
• Serous Membrane (pathology)
• Treatment Outcome
• Uterine Neoplasms (pathology, therapy)