Green tea polyphenol protection against 4-nitroquinoline 1-oxide-induced bone marrow lipid peroxidation and genotoxicity in Wistar rats.

Abstract

4-Nitroquinoline 1-oxide (4-NQO) a potent oral carcinogen, widely used for induction of oral carcinogenesis, has been found to induce lipid peroxidation in vivo and in vitro. Green tea contains a high content of polyphenols, which are potent antioxidants. Thus green tea polyphenols (GTP) might be expected play a protective role against 4-NQO induced lipid peroxidation and bone marrow toxicity. In the present study, a dose of 200 mg of GTP/kg b.wt/day was given orally for a week, simultaneously animals received 0.2 ml of 0.5% 4-NQO in propylene glycol (5 mg/ml) injected intramuscularly for three times/week. Oxidants and antioxidants such as malendialdehyde (MDA) and thiols, glutathione peroxidase (GPx), glutathione reductase (GR), superoxide dismutase (SOD) and catalase (CAT) were significantly decreased in 4-NQO induced animals except MDA, and these parameters were brought back to near normalcy on treatment with GTP. The results suggest that GTP treatment offers significant protection against 4-NQO induced lipid peroxidation and bone marrow toxicity and might be a promising potential candidate for prevention of mutations leading to cancer.

• Authors: Ashok Kumar Pandurangan, Srinivasan Periasamy, Suresh Kumar Anandasadagopan, Sudhandiran Ganapasam, Shyamala Devi Chennam Srinivasalu
• Journal: Asian Pacific journal of cancer prevention : APJCP (Asian Pac J Cancer Prev) Vol. 13 Issue 8 Pg. 4107-12 ( 2012) ISSN: 2476-762X [Electronic] Thailand
• PMID: 23098525 (Publication Type: Journal Article)

Chemical References

• Carcinogens
• DNA Adducts
• Polyphenols
• Tea
• Malondialdehyde
• 4-Nitroquinoline-1-oxide
• Catalase
• Glutathione Peroxidase
• Superoxide Dismutase
• Glutathione Reductase
• Glutathione

Topics

• 4-Nitroquinoline-1-oxide (toxicity)
• Animals
• Bone Marrow (drug effects, pathology)
• Carcinogens (toxicity)
• Catalase (metabolism)
• DNA Adducts (drug effects)
• DNA Damage (drug effects)
• Glutathione (metabolism)
• Glutathione Peroxidase (metabolism)
• Glutathione Reductase (metabolism)
• Immunoenzyme Techniques
• Lipid Peroxidation (drug effects)
• Male
• Malondialdehyde (metabolism)
• Oxidative Stress (drug effects)
• Polyphenols (pharmacology)
• Rats
• Rats, Wistar
• Superoxide Dismutase (metabolism)
• Tea (chemistry)