[Role of serum 25-hydroxyvitamin D in the diagnosis of vitamin D deficiency rickets].

Abstract

OBJECTIVE:

To study the role of serum 25-hydroxyvitamin D in the early diagnosis of vitamin D deficiency rickets.

METHODS:

Concentrations of serum 25(OH)D, calcium, phosphorus and alkaline phosphatase were measured in normal control (n=73), suspected rickets (n=45) and confirmed rickets groups (n=65). Receiver operating characteristic (ROC) curve was used to evaluate the diagnostic value of serum 25(OH)D for rickets.

RESULTS:

Serum 25(OH)D levels in the suspected and confirmed rickets groups were 83±30 and 72±31 nmol/L respectively, which was lower than in the normal control group (112±37 nmol/L) (P<0.01). There was no significant difference between the suspected and confirmed rickets groups (P>0.05). Vitamin D deficiency rates in the suspected and confirmed rickets groups were higher than in the control group (P<0.01). The ROC curve area of serum 25(OH)D for the diagnosis of rickets was 0.760 (95%CI 0.692-0.820, P<0.01), and the optimal operating point was 90.70 nmol/L (sensitivity 68.49%, specificity 72.73%). There was no significant difference in levels of calcium, phosphorus and alkaline phosphatase between the three groups (P>0.05).

CONCLUSIONS:

Serum 25(OH)D levels in infants with suspected and confirmed rickets are significantly reduced and this may reflect vitamin D deficiency . Therefore, it may be useful to check serum 25(OH)D levels in screening for rickets.

• Authors: Xiao-Yan Wang, Chun-Hua Jin, Jian-Xin Wu, Zhuo Liu, Mei Li, Na Li
• Journal: Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics (Zhongguo Dang Dai Er Ke Za Zhi) Vol. 14 Issue 10 Pg. 767-70 (Oct 2012) ISSN: 1008-8830 [Print] China
• PMID: 23092570 (Publication Type: Journal Article)

Chemical References

• Vitamin D
• 25-hydroxyvitamin D

Topics

• Female
• Humans
• Infant
• Male
• ROC Curve
• Rickets (blood, diagnosis)
• Vitamin D (analogs & derivatives, blood)