Abstract | OBJECTIVE: METHODS: RESULTS: Serum 25( OH)D levels in the suspected and confirmed rickets groups were 83±30 and 72±31 nmol/L respectively, which was lower than in the normal control group (112±37 nmol/L) (P<0.01). There was no significant difference between the suspected and confirmed rickets groups (P>0.05). Vitamin D deficiency rates in the suspected and confirmed rickets groups were higher than in the control group (P<0.01). The ROC curve area of serum 25( OH)D for the diagnosis of rickets was 0.760 (95%CI 0.692-0.820, P<0.01), and the optimal operating point was 90.70 nmol/L (sensitivity 68.49%, specificity 72.73%). There was no significant difference in levels of calcium, phosphorus and alkaline phosphatase between the three groups (P>0.05). CONCLUSIONS: Serum 25( OH)D levels in infants with suspected and confirmed rickets are significantly reduced and this may reflect vitamin D deficiency . Therefore, it may be useful to check serum 25( OH)D levels in screening for rickets.
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Authors | Xiao-Yan Wang, Chun-Hua Jin, Jian-Xin Wu, Zhuo Liu, Mei Li, Na Li |
Journal | Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics
(Zhongguo Dang Dai Er Ke Za Zhi)
Vol. 14
Issue 10
Pg. 767-70
(Oct 2012)
ISSN: 1008-8830 [Print] China |
PMID | 23092570
(Publication Type: Journal Article)
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Chemical References |
- Vitamin D
- 25-hydroxyvitamin D
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Topics |
- Female
- Humans
- Infant
- Male
- ROC Curve
- Rickets
(blood, diagnosis)
- Vitamin D
(analogs & derivatives, blood)
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