Abstract | INTRODUCTION:
Terpenoids constitute the largest class of natural products and are a rich reservoir of candidate compounds for drug discovery. Recent efforts into the research and development of anti- cancer drugs derived from natural products have led to the identification of a variety of terpenoids that inhibit cancer cell proliferation and metastasis via various mechanisms. Despite the increasing number of research reports, there lacks a comprehensive review of anti- cancer activity of terpenoids. AREAS COVERED: EXPERT OPINION: The anti- cancer activity of terpenoids appears promising and will potentially open more opportunities for cancer therapy. However, current studies are restricted to descriptive findings and lack mechanistic insights and systematic structure-activity relationship (SAR) studies. Future efforts into the systematic identification of the targets of terpenoids are believed to increase chances of gaining breakthrough insights in the field.
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Authors | Min Huang, Jin-Jian Lu, Ming-Qing Huang, Jiao-Lin Bao, Xiu-Ping Chen, Yi-Tao Wang |
Journal | Expert opinion on investigational drugs
(Expert Opin Investig Drugs)
Vol. 21
Issue 12
Pg. 1801-18
(Dec 2012)
ISSN: 1744-7658 [Electronic] England |
PMID | 23092199
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
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Chemical References |
- Antineoplastic Agents
- Biological Products
- Terpenes
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Topics |
- Animals
- Antineoplastic Agents
(pharmacology, therapeutic use)
- Biological Products
(pharmacology, therapeutic use)
- Humans
- Neoplasms
(drug therapy)
- Terpenes
(pharmacology, therapeutic use)
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