Bilateral Sertoli cell tumors of the testis-a likely new extracolonic manifestation of familial adenomatous polyposis.

Abstract

Testicular Sertoli cell tumors are rare and usually sporadic and unifocal. The large cell calcifying Sertoli cell tumor variant is known to be associated with Carney and Peutz-Jeghers syndromes and can be bilateral in these patient populations. There has been no documented association of Sertoli cell tumor with familial adenomatous polyposis (FAP) in the literature. The case presented is a bilateral Sertoli cell tumor occurring in a 34-year-old patient with FAP. The tumor had a conventional Sertoli cell tumor morphology, but with different morphology in the left and right sites. Beta-catenin immunostain showed strong nuclear reactivity in the tumor cells but not the nonneoplastic Sertoli cells. The presence of bilaterality as well as overexpression of beta-catenin by this tumor supports an association of the development of Sertoli cell tumor with the patient's FAP syndrome and adenomatous polyposis coli inactivation.

• Authors: Guang-Qian Xiao, Roberto C Granato, Pamela D Unger
• Journal: Virchows Archiv : an international journal of pathology (Virchows Arch) Vol. 461 Issue 6 Pg. 713-5 (Dec 2012) ISSN: 1432-2307 [Electronic] Germany
• PMID: 23090627 (Publication Type: Case Reports, Journal Article)

Chemical References

• beta Catenin

Topics

• Adenomatous Polyposis Coli (complications)
• Adult
• Humans
• Male
• Sertoli Cell Tumor (complications, pathology)
• Sertoli Cells (metabolism)
• Testicular Neoplasms (etiology)
• Testis (pathology)
• beta Catenin (biosynthesis)