Daptomycin concentrations in valve tissue and vegetation in patients with bacterial endocarditis.

Abstract

In a patient with mitral-aortic native-valve Streptococcus oralis endocarditis, daptomycin concentrations in aortic and mitral valves were 8.6 and 30.8 μg/g, respectively, and 26 μg/g in the mitral vegetation. In the case of porcine-aortic-valve Staphylococcus epidermidis endocarditis, the daptomycin concentrations were 53.1 μg/g in the valve and 18.1 μg/g in perivalvular tissues. Daptomycin achieved apparently adequate tissue concentrations. S. epidermidis was eradicated, whereas Streptococcus oralis persisted, and its daptomycin MIC displayed a 4-fold increase.

• Authors: Carlo Tascini, Antonello Di Paolo, Roberta Poletti, Sarah Flammini, Michele Emdin, Ilaria Ciullo, Enrico Tagliaferri, Annette Moter, Francesco Menichetti
• Journal: Antimicrobial agents and chemotherapy (Antimicrob Agents Chemother) Vol. 57 Issue 1 Pg. 601-2 (Jan 2013) ISSN: 1098-6596 [Electronic] United States
• PMID: 23089753 (Publication Type: Case Reports, Journal Article)

Chemical References

• Anti-Bacterial Agents
• Daptomycin

Topics

• Aged
• Animals
• Anti-Bacterial Agents (pharmacokinetics, pharmacology, therapeutic use)
• Aortic Valve (pathology, surgery)
• Bioprosthesis (microbiology)
• Daptomycin (pharmacokinetics, pharmacology, therapeutic use)
• Endocarditis, Bacterial (drug therapy, microbiology)
• Heart Valve Prosthesis (microbiology)
• Humans
• Male
• Middle Aged
• Mitral Valve (pathology, surgery)
• Staphylococcal Infections (drug therapy, microbiology)
• Staphylococcus (drug effects, growth & development)
• Staphylococcus epidermidis (drug effects, growth & development)
• Swine