Risk of lung cancer from radon exposure: contribution of recently published studies of uranium miners.

Abstract

The International Commission on Radiological Protection (ICRP) recently estimated the risk of lung cancer associated with radon exposure, and a statement was issued in ICRP Publication 115. This was based on recent epidemiological studies and the results from a joint analysis of cohorts of Czech, French, and German uranium miners, and indicated that the excess relative risk of lung cancer per unit of exposure should be expressed with consideration of chronic exposure over more than 10 years, by modelling time since median exposure, age attained or age at exposure, and taking in account, if possible, interaction between radon and tobacco. The lifetime excess absolute risk (LEAR) calculated from occupational exposure studies is close to 5 × 10(-4) per working level month (WLM) (14 × 10(-5) per hmJ/m(3)). LEAR values estimated using risk models derived from both miners and domestic exposure studies are in good agreement after accounting for factors such as sex, attained age, and exposure scenario. A sensitivity analysis highlighted the high dependence of background mortality rates on LEAR estimates. Using lung cancer rates among Euro-American males instead of the ICRP reference rates (males and females, and Euro-American and Asian populations), the estimated LEAR is close to 7 × 10(-4) per WLM (20 × 10(-5) per hm J/m(3)).

• Authors: M Tirmarche, J Harrison, D Laurier, E Blanchardon, F Paquet, J Marsh
• Journal: Annals of the ICRP (Ann ICRP) 2012 Oct-Dec Vol. 41 Issue 3-4 Pg. 368-77 ISSN: 1872-969X [Electronic] England
• PMID: 23089036 (Publication Type: Journal Article, Review)
• Copyright: Copyright © 2012. Published by Elsevier Ltd.

Chemical References

• Uranium
• Radon

Topics

• Dose-Response Relationship, Radiation
• Environmental Exposure
• Guidelines as Topic
• Humans
• International Agencies
• Lung Neoplasms (epidemiology, etiology)
• Mining
• Neoplasms, Radiation-Induced (epidemiology, etiology)
• Occupational Diseases (epidemiology, etiology)
• Occupational Exposure
• Radiation Protection (standards)
• Radon (toxicity)
• Risk Assessment
• Sensitivity and Specificity
• Uranium