Surgical second-look in high risk gastrointestinal stromal tumor of small intestine: A case report.

Abstract

INTRODUCTION:

The peritoneum is one of the most common sites of distant gastrointestinal stromal tumor (GIST) metastases. In particular, GIST arising from the small intestine with resected minimal synchronous macroscopic peritoneal carcinomatosis or with primary tumor rupture has a higher risk of developing peritoneal recurrence. Current clinical practice does not envisage second-look surgery in GIST patients at high risk of developing peritoneal recurrence, and no literature data are available.

PRESENTATION OF CASE:

We describe a 45-year-old woman who underwent emergency surgical resection of jejunal GIST presenting with spontaneous tumor rupture, synchronous ovarian and minimal macroscopic peritoneal involvement, and subsequent second-look surgery after 13 months of imatinib treatment.

DISCUSSION:

Second-look surgery confirmed a 2.6cm lesion close to the mesenteric border of the fourth jejunal loop, and 11 peritoneal lesions with a macroscopic necrotic aspect related to treatment response. After conversion to an open procedure, a segmental jejunal resection was performed with removal of all peritoneal lesions and macroscopic radical cytoreduction.

CONCLUSION:

Second-look surgery in selected GIST patients may be performed after at least 12 months of medical treatment with tyrosine-kinase inhibitors to identify those patients with limited peritoneal disease not disclosed by instrumental imaging who could undergo radical cytoreduction of peritoneal lesions.

• Authors: Margherita Nannini, Maria Abbondanza Pantaleo, Fausto Catena, Stefania Romano, Salvatore Tondo, Maria Giulia Pirini, Cristian Lolli, Alessandra Maleddu, Anna Mandrioli, Lidia Gatto, Maristella Saponara, Maria Caterina Pallotti, Angelo Paolo Dei Tos, Antonio Daniele Pinna, Guido Biasco
• Journal: International journal of surgery case reports (Int J Surg Case Rep) Vol. 4 Issue 1 Pg. 7-10 ( 2013) ISSN: 2210-2612 [Print] Netherlands
• PMID: 23088904 (Publication Type: Journal Article)
• Copyright: Copyright © 2012 Surgical Associates Ltd. Published by Elsevier Ltd. All rights reserved.