Abstract | OBJECTIVE: To investigate whether inhaled sevoflurane is capable of producing delayed cardioprotection effect in rats and its underlying mechanisms. METHODS: RESULTS: 1.0 MAC sevoflurane and 1.5 MAC sevoflurane improved cardiac pump function after reperfusion and reduced myocardial infarct size with the increased iNOS expression (P<0.05). However,the expression of eNOS and p-eNOS was not affected (P>0.05). A selective iNOS inhibitor 1400 W abolished the cardioprotection effect induced by inhalation of 1.0 MAC sevoflurane for 24 h. CONCLUSION:
Sevoflurane produces delayed cardioprotection through the up-regulation of iNOS expression.
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Authors | Lei-lei Ma, Feng-jiang Zhang, Min Yan |
Journal | Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences
(Zhejiang Da Xue Xue Bao Yi Xue Ban)
Vol. 41
Issue 5
Pg. 553-8
(Sep 2012)
ISSN: 1008-9292 [Print] China |
PMID | 23086649
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anesthetics, Inhalation
- Methyl Ethers
- Sevoflurane
- Nitric Oxide Synthase Type II
- Nos2 protein, rat
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Topics |
- Anesthetics, Inhalation
(pharmacology)
- Animals
- Disease Models, Animal
- Ischemic Preconditioning, Myocardial
- Male
- Methyl Ethers
(pharmacology)
- Myocardial Reperfusion Injury
(enzymology, pathology, prevention & control)
- Myocardium
(enzymology, pathology)
- Nitric Oxide Synthase Type II
(metabolism)
- Rats
- Rats, Sprague-Dawley
- Sevoflurane
- Up-Regulation
(drug effects)
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