HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Assessment of corneal hydration sensing in the terahertz band: in vivo results at 100 GHz.

Abstract
Terahertz corneal hydration sensing has shown promise in ophthalmology applications and was recently shown to be capable of detecting water concentration changes of about two parts in a thousand in ex vivo corneal tissues. This technology may be effective in patient monitoring during refractive surgery and for early diagnosis and treatment monitoring in diseases of the cornea. In this work, Fuchs dystrophy, cornea transplant rejection, and keratoconus are discussed, and a hydration sensitivity of about one part in a hundred is predicted to be needed to successfully distinguish between diseased and healthy tissues in these applications. Stratified models of corneal tissue reflectivity are developed and validated using ex vivo spectroscopy of harvested porcine corneas that are hydrated using polyethylene glycol solutions. Simulation of the cornea's depth-dependent hydration profile, from 0.01 to 100 THz, identifies a peak in intrinsic reflectivity contrast for sensing at 100 GHz. A 100 GHz hydration sensing system is evaluated alongside the current standard ultrasound pachymetry technique to measure corneal hydration in vivo in four rabbits. A hydration sensitivity, of three parts per thousand or better, was measured in all four rabbits under study. This work presents the first in vivo demonstration of remote corneal hydration sensing.
AuthorsDavid Bennett, Zachary Taylor, Pria Tewari, Sijun Sung, Ashkan Maccabi, Rahul Singh, Martin Culjat, Warren Grundfest, Jean-Pierre Hubschman, Elliott Brown
JournalJournal of biomedical optics (J Biomed Opt) Vol. 17 Issue 9 Pg. 97008-1 (Sep 2012) ISSN: 1560-2281 [Electronic] United States
PMID23085925 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)
Chemical References
  • Water
Topics
  • Algorithms
  • Animals
  • Body Water (metabolism)
  • Cornea (chemistry)
  • Rabbits
  • Reproducibility of Results
  • Sensitivity and Specificity
  • Terahertz Spectroscopy (methods)
  • Water (analysis)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: