Innate immune sensing of HIV-1 by dendritic cells.

Abstract

HIV-1-specific antibodies and CD8(+) cytotoxic T cells are detected in most HIV-1-infected people, yet HIV-1 infection is not eradicated. Contributing to the failure to mount a sterilizing immune response may be the inability of antigen-presenting dendritic cells (DCs) to sense HIV-1 during acute infection, and thus the inability to effectively prime naive, HIV-1-specific T cells. Recent findings related to DC-expressed innate immune factors including SAMHD1, TREX1, and TRIM5 provide a molecular basis for understanding why DCs fail to adequately sense invasion by this deadly pathogen and suggest experimental approaches to improve T cell priming to HIV-1 in prophylactic vaccination protocols.

• Authors: Jeremy Luban
• Journal: Cell host & microbe (Cell Host Microbe) Vol. 12 Issue 4 Pg. 408-18 (Oct 18 2012) ISSN: 1934-6069 [Electronic] United States
• PMID: 23084911 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Review)
• Copyright: Copyright © 2012 Elsevier Inc. All rights reserved.

Chemical References

• Antiviral Restriction Factors
• Carrier Proteins
• Phosphoproteins
• Tripartite Motif Proteins
• TRIM5 protein, human
• Ubiquitin-Protein Ligases
• Exodeoxyribonucleases
• three prime repair exonuclease 1
• SAM Domain and HD Domain-Containing Protein 1
• SAMHD1 protein, human
• Monomeric GTP-Binding Proteins

Topics

• Antiviral Restriction Factors
• Carrier Proteins (immunology, metabolism)
• Dendritic Cells (immunology)
• Exodeoxyribonucleases (immunology, metabolism)
• Gene Expression
• HIV-1 (immunology)
• Immunity, Innate
• Monomeric GTP-Binding Proteins (immunology, metabolism)
• Phosphoproteins (immunology, metabolism)
• SAM Domain and HD Domain-Containing Protein 1
• T-Lymphocytes (immunology)
• Tripartite Motif Proteins
• Ubiquitin-Protein Ligases