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Case of spontaneous regression of carotid body tumor in a SDHD mutant: a discussion on potential mechanisms based on a review of the literature.

AbstractBACKGROUND:
Head and neck paragangliomas are tumors associated with the parasympathetic nerve system and typically show an indolent growth pattern. Therefore a conservative management strategy is considered in selected cases.
METHODS AND RESULTS:
We present a case of a female patient who presented in 2003 with bilateral carotid body tumors and a tympanic tumor, associated with a mutation in the succinate dehydrogenase -sub-unit-D (SDHD). She was operated on the right carotid body tumor and the tympanic tumor. Thereafter the follow-up was performed with MR examinations at 2-year intervals. After an initial stable phase, over the last 3 years a spontaneous near-total regression of the contralateral carotid body tumor was observed, with only subtle rest-abnormalities visible in 2011.
CONCLUSIONS:
The present case underlines the indolent growth pattern of head and neck paragangliomas and for the first time describes a rare manifestation of spontaneous regression of a carotid body tumor. The literature was reviewed to discuss this phenomenon.
AuthorsSebastiaan Hammer, Jeroen C Jansen, Eleonora P M van der Kleij-Corssmit, Frederik J Hes, Mark C Kruit
JournalWorld journal of surgical oncology (World J Surg Oncol) Vol. 10 Pg. 218 (Oct 19 2012) ISSN: 1477-7819 [Electronic] England
PMID23083338 (Publication Type: Case Reports, Journal Article, Review)
Chemical References
  • SDHD protein, human
  • Succinate Dehydrogenase
Topics
  • Adult
  • Carotid Body Tumor (genetics, pathology, surgery)
  • Female
  • Humans
  • Mutation
  • Neoplasm Regression, Spontaneous
  • Succinate Dehydrogenase (genetics)

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