Abstract |
We reviewed the clinical course in 43 patients from eight medical centers who were given the diagnosis of chronic mucocutaneous candidiasis, a rare disorder of unknown cause that may occur in childhood. Recurrent or severe infections with organisms other than Candida were seen in 80% of the patients. There were nine cases of septicemia. Seven patients have died; six of these deaths were directly related to non-Candida infectious complications. Endocrine dysfunction, including Addison disease (11 patients) and hypothyroidism (9 patients), was seen in 19 of 43 patients. Immunologic studies failed to reveal a consistent abnormality, although two of five patients with reversed T4/T8 ratios are among those who have died. Ketoconazole was effective in controlling symptoms of candidiasis in most patients. The findings from this study indicate that non- Candida infections cause serious morbidity and may result in death in patients with chronic mucocutaneous candidiasis.
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Authors | H G Herrod |
Journal | The Journal of pediatrics
(J Pediatr)
Vol. 116
Issue 3
Pg. 377-82
(Mar 1990)
ISSN: 0022-3476 [Print] United States |
PMID | 2308026
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Immunoglobulin A
- Immunoglobulin G
- Amphotericin B
- Flucytosine
- Ketoconazole
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Topics |
- Adolescent
- Amphotericin B
(therapeutic use)
- Autoimmune Diseases
(epidemiology)
- Candidiasis
(complications)
- Candidiasis, Chronic Mucocutaneous
(complications, drug therapy, immunology)
- Child
- Child, Preschool
- Endocrine System Diseases
(complications)
- Family
- Female
- Flucytosine
(therapeutic use)
- Humans
- Immunoglobulin A
(metabolism)
- Immunoglobulin G
(metabolism)
- Incidence
- Infant
- Infections
(complications, epidemiology, mortality)
- Ketoconazole
(adverse effects, therapeutic use)
- Lung Diseases
(complications)
- Male
- Survival Rate
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