Association between angiotensin-converting enzyme insertion/deletion gene polymorphism and end-stage renal disease susceptibility.

Abstract

BACKGROUND AND OBJECTIVE:

The association between angiotensin-converting enzyme (ACE) insertion/deletion (I/D) gene polymorphism and end-stage renal disease (ESRD) risk is still controversial. A meta-analysis was performed to evaluate the association between ACE I/D gene polymorphism and ESRD susceptibility.

METHOD:

A predefined literature search and selection of eligible relevant studies were performed to collect data from electronic databases.

RESULTS:

Thirty-four articles were identified for the analysis of an association between ACE I/D gene polymorphism and ESRD risk. Both D allele and DD genotype were associated with ESRD susceptibility in overall populations (D: OR = 1.20, 95% CI: 1.06-1.36, p = 0.003, DD: OR = 1.47, 95% CI: 1.20-1.78, p = 0.0001) and in East Asians (D: OR = 1.34, 95% CI: 1.06-1.69, p = 0.01, DD: OR = 2.01, 95% CI: 1.29-3.12, p = 0.002). Only the DD genotype had a positive association with ESRD susceptibility in Caucasians (OR = 1.20, 95% CI: 1.01-1.43, p = 0.03). The result from sensitivity analysis in overall populations or Caucasians was similar to those in non-sensitivity analysis, but not among East Asians.

CONCLUSIONS:

The results of our study support the idea that D allele or DD genotype was associated with increased risk of ESRD susceptibility in the overall populations, and DD genotype was associated with ESRD susceptibility in Caucasians.

• Authors: Tian-Biao Zhou, Sheng-Sheng Yin, Yuan-Han Qin
• Journal: Journal of the renin-angiotensin-aldosterone system : JRAAS (J Renin Angiotensin Aldosterone Syst) Vol. 15 Issue 1 Pg. 22-31 (Mar 2014) ISSN: 1752-8976 [Electronic] England
• PMID: 23077080 (Publication Type: Journal Article, Meta-Analysis)

Chemical References

• ACE protein, human
• Peptidyl-Dipeptidase A

Topics

• Humans
• INDEL Mutation
• Peptidyl-Dipeptidase A (genetics)
• Polymorphism, Genetic