Cell-based tissue engineering augments tendon-to-bone healing in a rat supraspinatus model.
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| Abstract |
Rotator cuff pathology causes substantial pain/disability and health care costs. Cell-based tissue engineering offers promise for improved outcomes in tendon to bone healing. Cells from the tendon-bone interface were used here to amplify surgical defect healing in a rat model. Cells from tendon-to-bone interface of the rotator cuff were seeded in sponges and implanted into critical rotator cuff defects: Group I, control; II, surgical defect only; III, suture-repaired defect; IV, surgical defect, repair with sponge only; V, surgical defect, repair with sponge with cells. Three, 6-, and 12-week results were assessed for histologic features. At 3 weeks, histologic indices in Group V were significantly increased versus other treatment groups. Group V (12 weeks) showed significantly improved collagen organization versus other treatment groups; there was no difference in collagen organization in Group I versus V. In summary, increased cellularity, inflammation, vascularity, and collagen organization were present at 3 weeks; increased collagen organization at 12 weeks in Group V provides evidence for improved healing with cells. Data further support the utility of tendon-bone interface cells in rotator cuff healing.
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| Authors | Bryan J Loeffler, Brian P Scannell, Richard D Peindl, Patrick Connor, Daniel E Davis, Gretchen L Hoelscher, H James Norton, Edward N Hanley Jr, Helen E Gruber |
| Journal | Journal of orthopaedic research : official publication of the Orthopaedic Research Society (J Orthop Res) Vol. 31 Issue 3 Pg. 407-12 (Mar 2013) ISSN: 1554-527X [Electronic] United States |
| PMID | 23070709 (Publication Type: Journal Article) |
| Copyright | Copyright © 2012 Orthopaedic Research Society. |
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