Spray formulation can minimize
pain and irritation experience during the application of conventional
dosage forms.
Econazole Nitrate is an active ingredient of the
aerosol concentrate to be used for twice-daily application because of its long durability in the superficial layers of the fungal infected skin. The aim of this study is preliminary investigation of
Econazole Nitrate spray by varying the concentrations of different constituents of the spray. The ratios of
Propylene glycol (PG) and
isopropyl myristate (IPM) were selected as independent variables in 2(2) full factorial designs, keeping the concentration of
solvent, co-
solvent and propellant LPG constant.
Aerosol also contained
Ethanol as
solvent and
Isopropyl alcohol as co-
solvent. All ingredients of the
aerosol were packaged in an
aluminum container fitted with continuous-spray valves. Physical properties evaluated for the
Econazole Nitrate spray included delivery rate, delivery amount, pressure, minimum fill, leakage, flammability, spray patterns, particle image and plume angle. Glass containers were used to study incompatibility between concentrate and propellant due to the ease of visible inspection.
Isopropyl myristate at lower concentrate showed turbidity, while at high concentration it met the requirements for
aerosol and produced
Econazole Nitrate spray with expected characteristics.