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[Two cases of metastatic colorectal cancer in wild-type K-RAS effectively treated by panitumumab].

Abstract
Case 1 was a 58-year-old woman diagnosed with unresectable liver metastases from advanced rectal cancer. We performed laparoscopic low anterior resection for sigmoid cancer. As the first-line treatment, FOLFOX+bevacizumab(BV)was applied for 16 courses. The second-line treatment, FOLFIRI plus BV, was applied for four courses. However, the disease progressed with worsening liver metastases. The sequencing of K-RAS genes from the biopsy specimens of sigmoid colon cancer revealed an expression of a wild-type K-RAS. As the third-line treatment, panitumumab was applied. After 8 courses of this chemotherapy regimen, a significant reduction in the size of liver metastases was observed. Case 2 was an 81-year-old man diagnosed with unresectable liver metastases from advanced rectal cancer. We obliged the patient by performing laparoscopic rectal resection. As the first-line treatment, XELOX plus BV was applied for 10 courses. As the second-line treatment, IRIS was applied for 6 courses. However, this failed to prevent him from having a progressive disease. As the third-line treatment, panitumumab was applied for 2 courses, and a significant reduction in the size of liver metastases was observed. Our findings suggested that panitumumab has great potential for effective treatment of patients with unresectable stageIV colorectal cancer.
AuthorsYasuhiro Ishiyama, Masanori Kotake, Masashi Matsunaga, Hirotaka Kitamura, Michihiro Yamamoto, Noriyuki Inaki, Masaru Kurokawa, Hiroyuki Bando, Tetsuji Yamada
JournalGan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 39 Issue 10 Pg. 1567-70 (Oct 2012) ISSN: 0385-0684 [Print] Japan
PMID23064074 (Publication Type: Case Reports, English Abstract, Journal Article)
Chemical References
  • Antibodies, Monoclonal
  • Antineoplastic Agents
  • KRAS protein, human
  • Proto-Oncogene Proteins
  • panitumumab
  • ras Proteins
Topics
  • Aged, 80 and over
  • Antibodies, Monoclonal (therapeutic use)
  • Antineoplastic Agents (therapeutic use)
  • Fatal Outcome
  • Female
  • Humans
  • Liver Neoplasms (drug therapy, secondary)
  • Male
  • Middle Aged
  • Proto-Oncogene Proteins (genetics)
  • Rectal Neoplasms (drug therapy, pathology, surgery)
  • Sigmoid Neoplasms (drug therapy, pathology, surgery)
  • Treatment Outcome
  • ras Proteins (genetics)

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