Sulindac suppression of colorectal polyps in Gardner's syndrome.

Abstract

Sulindac causes both regression and suppression of colorectal polyps in patients with Gardner's syndrome and familial polyposis coli. Three patients with Gardner's syndrome and multiple colonic polyps had complete regression of polyps after two to three months of sulindac therapy. The implication that sulindac may prevent colorectal cancer and prophylactic surgery in patients with hereditary polyps of the colon is intriguing but has not yet been substantiated.

• Authors: W G Friend
• Journal: American family physician (Am Fam Physician) Vol. 41 Issue 3 Pg. 891-4 (Mar 1990) ISSN: 0002-838X [Print] United States
• PMID: 2305666 (Publication Type: Case Reports, Journal Article)

Chemical References

• Sulindac

Topics

• Adult
• Child
• Female
• Gardner Syndrome (drug therapy, genetics)
• Humans
• Male
• Middle Aged
• Pedigree
• Sulindac (adverse effects, therapeutic use)