Abstract | BACKGROUND: METHODS: Highly sensitive troponin T (hsTnT) was measured daily during the first 4 days in 193 consecutive patients with acute ischemic stroke without overt ACS or atrial fibrillation. The patients were previously tested normal with a fourth-generation TnT assay. The patients were followed for 47 months, with all-cause and cardiovascular mortality end-points. RESULTS: A total of 33.7% of the patients had hsTnT levels >14 ng/l following admission. Patients with increased hsTnT were older, had decreased hemoglobin levels and increased creatinine, NT-proBNP and CRP levels. hsTnT concentrations at admission were significantly higher in decedents than in survivors. After adjustment for stroke severity, C-reactive protein, age, NT-proBNP and prior heart and/or renal failure, hsTnT levels were not a significant predictor of long-term all-cause or cardiovascular mortality. CONCLUSION: Elevated levels of hsTnT are frequently present in patients with acute ischemic stroke previously tested normal with a fourth-generation TnT assay. hsTnT did not provide additional prognostic information in these subjects.
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Authors | J K Jensen, T Ueland, P Aukrust, L Antonsen, S R Kristensen, J L Januzzi, J Ravkilde |
Journal | European neurology
(Eur Neurol)
Vol. 68
Issue 5
Pg. 287-93
( 2012)
ISSN: 1421-9913 [Electronic] Switzerland |
PMID | 23051820
(Publication Type: Journal Article)
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Copyright | Copyright © 2012 S. Karger AG, Basel. |
Chemical References |
- Peptide Fragments
- Troponin T
- C-Reactive Protein
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Topics |
- Acute Coronary Syndrome
(blood, diagnosis)
- Aged
- Aged, 80 and over
- C-Reactive Protein
(metabolism)
- Female
- Humans
- Male
- Middle Aged
- Peptide Fragments
(blood)
- Prognosis
- Sensitivity and Specificity
- Stroke
(blood, diagnosis)
- Troponin T
(blood)
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