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Highly sensitive troponin T in patients with acute ischemic stroke.

AbstractBACKGROUND:
Newly developed troponin assays have superior diagnostic and prognostic performance in acute coronary syndrome (ACS), when compared to conventional troponin assays; however, highly sensitive troponin has not been evaluated in patients with acute ischemic stroke.
METHODS:
Highly sensitive troponin T (hsTnT) was measured daily during the first 4 days in 193 consecutive patients with acute ischemic stroke without overt ACS or atrial fibrillation. The patients were previously tested normal with a fourth-generation TnT assay. The patients were followed for 47 months, with all-cause and cardiovascular mortality end-points.
RESULTS:
A total of 33.7% of the patients had hsTnT levels >14 ng/l following admission. Patients with increased hsTnT were older, had decreased hemoglobin levels and increased creatinine, NT-proBNP and CRP levels. hsTnT concentrations at admission were significantly higher in decedents than in survivors. After adjustment for stroke severity, C-reactive protein, age, NT-proBNP and prior heart and/or renal failure, hsTnT levels were not a significant predictor of long-term all-cause or cardiovascular mortality.
CONCLUSION:
Elevated levels of hsTnT are frequently present in patients with acute ischemic stroke previously tested normal with a fourth-generation TnT assay. hsTnT did not provide additional prognostic information in these subjects.
AuthorsJ K Jensen, T Ueland, P Aukrust, L Antonsen, S R Kristensen, J L Januzzi, J Ravkilde
JournalEuropean neurology (Eur Neurol) Vol. 68 Issue 5 Pg. 287-93 ( 2012) ISSN: 1421-9913 [Electronic] Switzerland
PMID23051820 (Publication Type: Journal Article)
CopyrightCopyright © 2012 S. Karger AG, Basel.
Chemical References
  • Peptide Fragments
  • Troponin T
  • C-Reactive Protein
Topics
  • Acute Coronary Syndrome (blood, diagnosis)
  • Aged
  • Aged, 80 and over
  • C-Reactive Protein (metabolism)
  • Female
  • Humans
  • Male
  • Middle Aged
  • Peptide Fragments (blood)
  • Prognosis
  • Sensitivity and Specificity
  • Stroke (blood, diagnosis)
  • Troponin T (blood)

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