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Tianeptine in combination with monoamine oxidase inhibitors for major depressive disorder.

Abstract
Major depressive disorder may respond to monotherapy with monoamine oxidase inhibitors (MAOIs) or tianeptine. Literature search showed no reports of MAOIs combined with tianeptine. The method included was clinical case history. A 59-year-old woman had partial improvement of depression with the MAOI tranylcypromine combined with topiramate, trazodone and ziprasidone. The patient had further improvement of depression symptoms after addition of tianeptine. No adverse events were evident. The combination of MAIOs and tianeptine may be effective for refractory major depressive disorder.
AuthorsEdward H Tobe
JournalBMJ case reports (BMJ Case Rep) Vol. 2012 (Oct 09 2012) ISSN: 1757-790X [Electronic] England
PMID23048001 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Monoamine Oxidase Inhibitors
  • Thiazepines
  • tianeptine
Topics
  • Depressive Disorder, Major (drug therapy)
  • Drug Therapy, Combination
  • Female
  • Humans
  • Middle Aged
  • Monoamine Oxidase Inhibitors (therapeutic use)
  • Thiazepines (therapeutic use)

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