Two distinct epitopes on the ovalbumin 323-339 peptide differentiating CD4⁺T cells into the Th2 or Th1 phenotype.

Abstract

The epitopes for OVA323-339-specific CD4⁺T cells from OVA23-3 food allergy model and DO11.10 tolerant induction model mice were analyzed. We found that OVA23-3 CD4⁺T cells recognized the N-terminal region, showing strong proliferation and the Th2-phenotype, and that DO11.10 CD4⁺T cells recognized the C-terminal region, showing milder proliferation and a Th1-skewed response. These differences may regulate the responses of those mice to OVA-feeding, inflammation and tolerance.

• Authors: Haruyo Nakajima-Adachi, Emiko Koike, Mamoru Totsuka, Erika Hiraide, Yoshio Wakatsuki, Hiroshi Kiyono, Satoshi Hachimura
• Journal: Bioscience, biotechnology, and biochemistry (Biosci Biotechnol Biochem) Vol. 76 Issue 10 Pg. 1979-81 ( 2012) ISSN: 1347-6947 [Electronic] England
• PMID: 23047087 (Publication Type: Journal Article)

Chemical References

• Epitopes
• Peptide Fragments
• Ovalbumin

Topics

• Amino Acid Sequence
• Animals
• CD4-Positive T-Lymphocytes (cytology, immunology)
• Cell Differentiation (immunology)
• Epitopes (chemistry, immunology)
• Food Hypersensitivity (immunology)
• Mice
• Molecular Sequence Data
• Ovalbumin (chemistry)
• Peptide Fragments (chemistry, immunology)
• Phenotype
• Th1 Cells (cytology)
• Th2 Cells (cytology)