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Interferon-α for unresectable progressive and symptomatic plexiform neurofibromas.

Abstract
Neurofibromas are the most common manifestations of neurofibromatosis type-1. They occasionally cause pain or progressive loss of function due to nerve compression. Optimal treatment approach is still challenging and the current treatment results are not satisfactory. Four cases of plexiform neurofibromas with various clinical presentations and an addendum to a previously published report on a patient who had relief from pain and/or regression of tumor volume after treatment with interferon-α 2a are presented.
AuthorsRejin Kebudi, Fatma B Cakir, Omer Gorgun
JournalJournal of pediatric hematology/oncology (J Pediatr Hematol Oncol) Vol. 35 Issue 3 Pg. e115-7 (Apr 2013) ISSN: 1536-3678 [Electronic] United States
PMID23042022 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Antiviral Agents
  • Interferon-alpha
Topics
  • Antiviral Agents (therapeutic use)
  • Child
  • Child, Preschool
  • Female
  • Humans
  • Infant
  • Interferon-alpha (therapeutic use)
  • Male
  • Neurofibroma, Plexiform (drug therapy, pathology)
  • Neurofibromatosis 1 (drug therapy, pathology)
  • Prognosis
  • Retrospective Studies

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