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Severe neurological symptoms in a patient with advanced renal cell carcinoma treated with sunitinib.

Abstract
Neurological symptoms are uncommon in patients administered sunitinib therapy; however, a few cases of dramatic neurotoxicity attributable to the development of reversible posterior leukoencephalopathy syndrome have been reported. Here, we report a case of a 71-year old woman with severe neurological symptoms occurring during sunitinib therapy for metastatic renal cell carcinoma. The clinical symptoms were typical for reversible posterior leukoencephalopathy syndrome, but there were no accompanying neuroimaging abnormalities. A Naranjo probability score of 3 indicates the adverse drug reaction was possible, but we discuss other potential causes of this event.
AuthorsRenata Duchnowska, Beata Miciuk, Lubomir Bodnar, Leszek Waśniewski, Cezary Szczylik
JournalJournal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners (J Oncol Pharm Pract) Vol. 19 Issue 2 Pg. 186-9 (Jun 2013) ISSN: 1477-092X [Electronic] England
PMID23037634 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Antineoplastic Agents
  • Indoles
  • Pyrroles
  • Sunitinib
Topics
  • Aged
  • Antineoplastic Agents (adverse effects, therapeutic use)
  • Carcinoma, Renal Cell (drug therapy, pathology)
  • Female
  • Humans
  • Indoles (adverse effects, therapeutic use)
  • Kidney Neoplasms (drug therapy, pathology)
  • Neoplasm Metastasis
  • Neurotoxicity Syndromes (diagnosis, etiology, physiopathology)
  • Posterior Leukoencephalopathy Syndrome (chemically induced, diagnosis, physiopathology)
  • Pyrroles (adverse effects, therapeutic use)
  • Severity of Illness Index
  • Sunitinib

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