Abstract | INTRODUCTION: METHODS: RESULTS: A total of 23 studies (n = 1502 patients: n = 762 admitted to the ICU) were included. No statistically significant difference in mortality rate was found between patients receiving n-3 PUFA-enriched lipid emulsions and those receiving standard lipid emulsions (RR = 0.89; 0.59, 1.33), possibly reflecting a relatively low underlying mortality risk. However, n-3 PUFA-enriched emulsions are associated with a statistically and clinically significant reduction in the infection rate (RR = 0.61; 0.45, 0.84) and the lengths of stay, both in the ICU (-1.92; -3.27, -0.58) and in hospital overall (-3.29; -5.13, -1.45). Other beneficial effects included reduced markers of inflammation, improved lung gas exchange, liver function, antioxidant status and fatty acid composition of plasma phospholipids, and a trend towards less impairment of kidney function. CONCLUSIONS: These results confirm and extend previous findings, indicating that n-3 PUFAs-enriched parenteral nutrition regimens are safe and effective in reducing the infection rate and hospital/ICU stay in surgical and ICU patients.
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Authors | Lorenzo Pradelli, Konstantin Mayer, Maurizio Muscaritoli, Axel R Heller |
Journal | Critical care (London, England)
(Crit Care)
Vol. 16
Issue 5
Pg. R184
(Oct 04 2012)
ISSN: 1466-609X [Electronic] England |
PMID | 23036226
(Publication Type: Journal Article, Meta-Analysis, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Elective Surgical Procedures
(adverse effects)
- Fatty Acids, Omega-3
(administration & dosage)
- Humans
- Intensive Care Units
- Parenteral Nutrition
(methods)
- Postoperative Complications
(epidemiology, prevention & control)
- Randomized Controlled Trials as Topic
(methods)
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