[Inhibition of pancreatic stellate cell activation by lisinopril for prevention fibrogenesis in experimental chronic alcoholic pancreatitis].

Abstract

Lisinopril (angiotensin-converting enzyme inhibitor) attenuates fibrotic changes in pancreas after distal pancreatectomy in rats with experimental alcohol induced chronic pancreatitis. Lisinopril was administered after distal pancreatectomy in rats with experimental alcohol induced chronic pancreatitis. The animals were treated with lisinopril at the dose of 10 mg/kg body weight per day for 21 days after operation. To estimate the efficacy of the treatment on activity and number of pancreatic stellate cells the immunohistochemical investigation was made with alpha-smooth muscle actin (alpha-SMA), desmin, vimentin, glial fibrillary acidic protein (GFAP), matrix metalloproteinase-1 (MMP-1), tissue inhibitor of metalloproteinase-2 (TIMP-2) using. The treatment of rats after operation with lisinopril inhibite activity of pancreatic stellate cells and characterized by significant decrease of the alpha-SMA, desmin, GFAP, vimentin and TIMP-2 expression. The ratio of MMP-1/TIMP-2 was greater in the group with treatment then in the control group. This therapy had a trend to alleviate the fibrotic changes in pancreas.

• Authors: M E Nichitaĭlo, D A Kravchenko, E B Medvetskiĭ, I S Shpon'ka, I M Savitskaia
• Journal: Klinichna khirurhiia (Klin Khir) Issue 7 Pg. 52-6 (Jul 2012) ISSN: 0023-2130 [Print] Ukraine
• PMID: 23033781 (Publication Type: English Abstract, Journal Article)

Chemical References

• Angiotensin-Converting Enzyme Inhibitors
• Ethanol
• Lisinopril

Topics

• Angiotensin-Converting Enzyme Inhibitors (pharmacology)
• Animals
• Ethanol
• Fibrosis (etiology, pathology, prevention & control)
• Lisinopril (pharmacology)
• Male
• Pancreas (pathology)
• Pancreatectomy
• Pancreatic Stellate Cells (drug effects)
• Pancreatitis, Alcoholic (chemically induced, complications, drug therapy, pathology, surgery)
• Rats
• Rats, Wistar