Immune interference in the setting of same-day administration of two similar inactivated alphavirus vaccines: eastern equine and western equine encephalitis.

Abstract

We compared the effect on primary vaccination plaque-reduction neutralization 80% titers (PRNT80) responses of same-day administration (at different injection sites) of two similar investigational inactivated alphavirus vaccines, eastern equine encephalitis (EEE) vaccine (TSI-GSD 104) and western equine encephalitis (WEE) vaccine (TSI-GSD 210) to separate administration. Overall, primary response rate for EEE vaccine was 524/796 (66%) and overall primary response rate for WEE vaccine was 291/695 (42%). EEE vaccine same-day administration yielded a 59% response rate and a responder geometric mean titer (GMT)=89 while separate administration yielded a response rate of 69% and a responder GMT=119. WEE vaccine same-day administration yielded a 30% response rate and a responder GMT=53 while separate administration yielded a response rate of 54% and a responder GMT=79. EEE response rates for same-day administration (group A) vs. non-same-day administration (group B) were significantly affected by gender. A logistic regression model predicting response to EEE comparing group B to group A for females yielded an OR=4.10 (95% CL 1.97-8.55; p=.0002) and for males yielded an OR=1.25 (95% CL 0.76-2.07; p=.3768). WEE response rates for same-day administration vs. non-same-day administration were independent of gender. A logistic regression model predicting response to WEE comparing group B to group A yielded an OR=2.14 (95% CL 1.22-3.73; p=.0077). We report immune interference occurring with same-day administration of two completely separate formalin inactivated viral vaccines in humans. These findings combined with the findings of others regarding immune interference would argue for a renewed emphasis on studying the immunological mechanisms of induction of inactivated viral vaccine protection.

• Authors: Ronald B Reisler, Paul H Gibbs, Denise K Danner, Ellen F Boudreau
• Journal: Vaccine (Vaccine) Vol. 30 Issue 50 Pg. 7271-7 (Nov 26 2012) ISSN: 1873-2518 [Electronic] Netherlands
• PMID: 23031498 (Publication Type: Journal Article)
• Copyright: Copyright © 2012. Published by Elsevier Ltd.

Chemical References

• Antibodies, Neutralizing
• Antibodies, Viral
• Drug Carriers
• Viral Vaccines

Topics

• Adolescent
• Adult
• Aged
• Alphavirus (genetics, immunology)
• Antibodies, Neutralizing (blood)
• Antibodies, Viral (blood)
• Drug Carriers (administration & dosage)
• Drug Interactions
• Encephalitis Virus, Eastern Equine (genetics, immunology)
• Encephalitis Virus, Western Equine (genetics, immunology)
• Encephalomyelitis, Eastern Equine (prevention & control)
• Encephalomyelitis, Western Equine (prevention & control)
• Female
• Genetic Vectors
• Humans
• Male
• Middle Aged
• Time Factors
• Vaccination (methods)
• Viral Plaque Assay
• Viral Vaccines (administration & dosage)
• Young Adult