Extraosseous plasmacytoma with an aggressive course occurring solely in the CNS.

Abstract

Extraosseous (extramedullary) plasmacytoma is a relatively indolent neoplasm that constitutes 3-5% of all plasma cell neoplasms. Rare cases have been reported to truly occur in the CNS and not as an extension from a nasal lesion. EBV expression in plasma cell neoplasms has been reported in very few cases that are mainly post-transplant or occurring in severely immunosuppressed patients. We report a case of extraosseous plasmacytoma with an aggressive course in an HIV-positive individual that occurred solely in the CNS, showing EBV expression by in situ hybridization, and presenting as an intraparenchymal mass as well as in the CSF.

• Authors: William Wu, Whitney Pasch, Xiaohui Zhao, Sherif A Rezk
• Journal: Neuropathology : official journal of the Japanese Society of Neuropathology (Neuropathology) Vol. 33 Issue 3 Pg. 320-3 (Jun 2013) ISSN: 1440-1789 [Electronic] Australia
• PMID: 23025535 (Publication Type: Case Reports, Journal Article)
• Copyright: © 2012 Japanese Society of Neuropathology.

Topics

• Adult
• Brain (pathology)
• Central Nervous System Neoplasms (drug therapy, pathology)
• Epstein-Barr Virus Infections (complications, pathology)
• Fatal Outcome
• HIV Seropositivity (complications)
• Humans
• Immunohistochemistry
• In Situ Hybridization
• Magnetic Resonance Imaging
• Male
• Plasmacytoma (drug therapy, pathology)
• Tomography, X-Ray Computed